Chelsea Handler's US talk show will end on August 26.
The 39-year-old presenter - who confirmed in March she intended to leave 'Chelsea Lately' at the end of her contract - will depart E! three months before her current agreement comes to an end, and is delighted with the work she did for the network.
Chelsea said in a statement: "I myself am more surprised than anyone that I was able to hold down a job for seven years, and it was a fantastic seven years.
"I will always look back at my time on E! as most people look back at their time in college. I'm glad I went."
Suzanne Kolb, the president of E!, praised the star for adding "a distinct voice to late night with her acerbic wit and fearless commentary."
Until the station develops a possible replacement show, it will air E! News in the 11pm slot.
Chelsea - who is believed to have made around $9 million a year from the show - has previously voiced her concerns about the E! network and described it as "a sad, sad place to live."
She also said: "They don't know what they're doing. They have no ideas. It's a failure."
It is rumoured the comic will land a new contract with online streaming service Netflix.

Brad Pitt loves being a "farmer".
The 'Moneyball' actor and his fiancee Angelina Jolie - with who he raises children Maddox, 12, Pax, 10, Zahara, nine, Shiloh, seven, and twins Knox and Vivienne, five - bought French winery Miraval in 2012 and the 50-year-old hunk loves learning more about the vineyard and the winemaking process as he finds it so relaxing.
He said: "I'm a farmer now. I love learning about the land and which field is most suitable for which grape, the drama of September and October...I enjoy cleaning the forest and walking the land. [It is] the antithesis of the drive, the want, the need to get ahead indicative of life in Hollywood."
Brad and Angelina paid $60 million for the winery and, after deciding to tackle their new business venture "like a film", have seen production grow from 5,800 cases in 2011 to 16,000 now.
Speaking to Wine Spectator magazine, Brad said: "The business model didn't make sense to me...Let's approach it like a film...let's make something we can be proud of and all people can enjoy."

Justin Bieber climbed over a 6ft fence to meet waiting fans.
The 'Believe' hitmaker scaled the metal railings after spotting a group of young females waiting outside his Los Angeles recording studio on Tuesday (27.05.14) evening, and happily posed for pictures and signed autographs.
The 20-year-old singer - who wore a white t-shirt, jeans and a heavy gold chain - even gave one of the fans a kiss after climbing the barrier.
Justin agreed to paparazzi requests to pose for pictures, but added: "I just wanna say hi to my fans."
The troubled star is said to be "trying to be a better person" after a number of recent controversies, including being arrested for driving under the influence (DUI) and getting into altercations with members of the public for allegedly taking pictures of him.
And Justin, who donated $545,000 to AIDS/ HIV research at the amfAR's 21st Cinema Against AIDS Gala in Antibes, France last week, recently urged fans not to believe everything they read about him and insisted he wants to be a good person.
He tweeted: "My mom raised me to be kind to others. I get judged, harassed, and I try to take the high road. Sometimes it isn't easy. But we keep trying.
"I will continue to be the man my mother raised. I love people and I will try to be kind even when things are not fair. Don't believe rumors. (sic)"

Sandra Bullock has reportedly been growing closer to Chris Evans.
The 49-year-old actress is said to have been "flirting" and seeing more of her friend - who previously confessed to a boyhood crush on the brunette beauty - and now pals are desperate for them to officially embark on a relationship.
A source told America's OK! magazine: "They have been talking more than ever and they flirt anytime they spend time together. She's been his dream girl for most of his life, so it would be a fairy-tale ending for Chris.
"Friends are pressing Sandra to just finally give in and take their relationship to the next level. It's just a matter of time."
Sandra - who has a four-year-old adopted son, Louis - and Chris, 32, showed their "connection" at Hollywood eatery Cecconi's earlier this month, leaving their mutual pal and fellow dinner guest Chelsea Handler feeling awkward.
An onlooker said: "Chelsea looked like the odd man out - Sandy and Chris were talking and joking with each other for much of the time.
"Chelsea kept chiming in and they would include her but there seemed to be a connection between Chris and Sandy."
Friends of the 'Blind Side' star now hope the 'Captain America' actor can restore Sandra's faith in men following her divorce from Jesse James in 2010 amid revelations he had cheated on her with several women.

Britain's Prince Harry supported his grandmother Queen Elizabeth at a special parade yesterday (28.05.14).
The 29-year-old royal joined other members of the royal family, including Princess Anne and Prince Edward, at the prestigious Horse Guards Parade in Whitehall, London, where the 88-year-old monarch was the centre of attention.
Despite the rain, the family were in good spirits and the Queen attended the event with her 92-year-old husband, Prince Philip.
Ahead of the ceremony the couple were driven around the parade in a Bentley, rather than an open-top vehicle, and the prince then saluted at the start of the event, as Harry proudly watched his grandparents from the side.
The Queen smiled as she presented new standards to officers from the Household Cavalry's Blues and Royals and Life Guards and praised the troops.
She said: "I have received so many complimentary so many complimentary remarks from visiting Heads of State, who have witnessed the excellence of tour turnout and horsemanship at close quarters.
"A generation of soldiers has now served within the single Regiment while successfully maintaining the traditions and separate identities of the Life Guards and the Blues and Royals."
According to Hellomagazine.com, she added: "The values and ethos of the Household Cavalry as a whole are embedded within the fabric of these Standards which are emblazoned with the hard-won honours of the past."

TV show 'I Wanna Marry Harry' will be aired in the UK.
The reality programme, which sees 12 American women try and win over a man they think is Britain's Prince Harry, premièred in the US last week and will now be shown on ITV2 in the UK from June 4.
The show stars Prince Harry lookalike Matthew Hicks, which has been given a course in etiquette, fine dining and horseback riding, to make sure he's convincing as the 29-year-old royal.
The female contestants will go on a series of dates with the flame-haired hunk and one girl will be eliminated each week until there is a final winner, who will believe she is being given the option to marry a real prince after winning his heart.
She will have to decide if she is really in love with the prince, or whether she just wanted to date him because of his royal blood.
The show is already popular in America, where it is aired on FOX, and Matthew's identity will only be revealed at the end of the show.
The programme's tagline reads: "Will he be able to convince them he's regal, and if he does, will they fall for the crown or fall in love with the real him?"
It is being produced by Ryan Seacrest and ZigZag Productions and was put into development last year under the title 'Dream Date'.
The real prince, who is now single after splitting from girlfriend Cressida Bonas, is yet to comment on the show.

Britain's Duchess Catherine and Prince William will visit Scotland today (29.05.14) where they will bottle their own malt whiskey. The royal couple, who will carry out their first official engagement since returning from their tour of Australia and N...

Britain's Prince Harry will visit Suffolk today (29.05.14).
The 29-year-old royal, who attended the prestigious Horse Guards Parade in Whitehall, London yesterday to support his grandmother, Queen Elizabeth, will meet charity workers from Inspire Suffolk and take part in rugby and football coaching sessions with youngsters and talk to people taking part in The Prince's Trust Team Programme, before heading to the Suffolk Show.
Organisers of the annual agricultural event, held in Ipswich, claim the royal visit will be a "wonderful boost".
The prince will stop by the Farm Discovery Zone to meet young farmers before watching a Royal British Legion parade at the event, which attracts more than 80,000 visitors every years.
Show director Bill Baker told the BBC he hoped the prince's visit will held to appeal to young people to take an interest in farming and consider it as a future career.
He said: "The prince enjoys a strong public following and his visit is especially appreciated in a year when we are working to appeal to more young people at the show and presenting the kinds of careers available to them in the food and farming related industries."
The 29-year-old royal has close links to Suffolk, having been based at Wattisham Airfield during his time in the Armed Forces.

One Direction think Chris Martin is "one of the coolest men in music".
The 'You & I' hitmakers performed at BBC Radio 1's Big Weekend in Glasgow last week before the 37-year-old star took to the same stage with his band Coldplay, and Liam Payne has admitted he has a lot of admiration for him.
Quizzed on how One Direction felt about Chris referring to them as "brilliant", Liam exclusively told Radio 1's Scott Mills: "It's the best thing ever. For us, from the start, we've always been a little bit ridiculed because of being on the X Factor and people say it's the easy route or whatever.
"Then because some of the songs that we've released are on the 'poppy' side of things. So it's like we do get a bit of stick from certain music groups or whatever like, 'They're not cool.'
"But to have somebody who is literally one of the coolest men in music confirm for you that, 'No these boys are alright', that is huge for us."
Despite Liam and his bandmates - Harry Styles, Zayn Malik, Niall Horan and Louis Tomlinson - admitting they are huge fans of Coldplay, Chris has confessed he knows his band aren't "cool" and says he doesn't care.
He told the Daily Star newspaper: "We've never been the coolest thing or the most fashionable thing. Well, maybe for a period.
"It just feels like we're able to keep rolling and no-one really notices.
"I feel like every day we're given is a real blessing. I could not have asked for a more dreamy job."
Scott's full interview with the boys will air on Radio 1 at 2pm this afternoon (29.05.14) and an exclusive 45 minute-long BBC iPlayer programme 'One Direction - This Is Them ... At The Big Weekend' will go live at 3pm.

Dr. Dre has secured a deal to sell his Beats Music business to Apple for $3 billion, making him the richest artist in hip-hop.
The co-founder, who launched the headphones and streaming service with friend Jimmy Lovine, will leave Interscope, which he founded, to work with Apple alongside his business partner.
According to NME.com, Dre said: "I've always known in my heart that Beats belonged with Apple.
"The idea when we started the company was inspired by Apple's unmatched ability to marry culture and technology.
"Apple's deep commitment to music fans, artists, songwriters and the music industry is something special."
Dre could be set to become hip-hop's first billionaire after Apple announced they will buy the business for $2.6 billion, as well as spending $400 million "that will vest over time".
Talking about the deal, which has been rumoured for weeks, Apple's CEO Tim Cook said: "Music is such an important part of all of our lives and holds a special place within our hearts at Apple.
"That's why we have kept investing in music and are bringing together these extraordinary teams so we can continue to create the most innovative music products and services in the world."
Beats earned Dre $200 million last year, making his total net worth about $550 million, but the new deal with boost his fortune and put him ahead of Puff Daddy, who was previously the richest artist in hip-hop with $700 million, according to Forbes magazine.

Bon Jovi guitarist Richie Sambora has debuted a new song which he hopes will help drug addicts.
The 54-year-old musician has written the track, 'Lighthouse,' which he played at an event raising awareness about heroin and painkiller abuse in New Jersey, and proceeds from its sale will go towards a drug treatment facility which is planned for the region.
According to the Associated Press, Richie, who has battled drug addiction himself, had originally named the song 'Needles on the Shore', but decided to change it because he wanted to do something "optimistic" which would be a "beacon of light and hope" for people battling addiction.
He said: "Everyone needs that light when they're far off the shore." The song's lyrics include: "Those who matter don't judge/ When you're swimming with the tide in the wake of a flood."
During the gig, Richie spoke about his own past drug abuse after spending time in rehab and said: "I got first-hand experience. I never did heroin, but obviously I did other stuff."
The guitarist and father-of-one, who insists he is now drug-free, wanted to take part in the event because he admits he is "scared" about what his 16-year-old daughter Ava, with ex-wife Heather Locklear, could end up being involved in when she gets older.
He said: "We can't be scared silent. Together we can make a difference because this epidemic has to stop."
Meanwhile, Richie is taking a break from Bon Jovi, having cited "personal issues" in April 2013, and he insisted that drugs played no part in his decision to spend some time apart from the group.
He claims the band took on too much work and he plans to rejoin the band, although he has not decided when he will play with them again.

Lady Gaga has cancelled two shows after being struck down with bronchitis.
The 28-year-old singer was forced to pull out of a gig in Seattle last night (28.05.14) and has cancelled a further show in Vancouver on the American leg of her 'artRAVE Tour' due to the illness.
She took to Twitter today (29.05.14) to apologise to fans for the inconvenience, writing: "I'm devastated I'm unable to perform this week. Ursula took my mermaid voice. I've come down with horrible Bronchitis (sic)," making reference to the fictional sea witch from 'The Little Mermaid', who uses Ariel's voice to cast a spell in the popular Disney movie.
Gaga also insisted she would reschedule the cancelled shows so fans could see her live, posting: "My deepest apologies to Seattle and Vancouver, we'll reschedule those shows & be back to make it up to you. I <3 monsters. #sadgaga (sic)."
Fans were quick to wish her well and she posted: "Thanks for understanding," adding, "Im so sorry. I'm holding stuffies and wearing seashell bra. With tissues and wigs. (sic)"
Meanwhile, the star is set to head to the UK in October and has added a number of extra arena shows in Birmingham, Sheffield, Newcastle and Glasgow after a massive demand for tickets.
She has also added a third date at London's O2 Arena to her UK and Ireland tour schedule, after the first two nights sold out just minutes after tickets going on sale.